品质保障》

科技园区独立标准实验室检测,产品质量可靠有保证;由从事生命科学研究的高级技术人才售后提供技术支持,让您买的放心,用的省心。

FITC标记的乙酰辅酶A结合蛋白抗体
品名:
FITC标记的乙酰辅酶A结合蛋白抗体
货号:
DL-1195
英文:
Anti-Diazepam Binding Inhibitor/FITC
英文缩写:
background:
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
 
Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
 
Subunit:
Monomer.
 
Subcellular Location:
Endoplasmic reticulum. Golgi apparatus.Note=Golgi localization is dependent on ligand binding.
 
Tissue Specificity:
Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.